Testing for recombinant human erythropoietin
نویسندگان
چکیده
منابع مشابه
Testing for recombinant human erythropoietin.
ERYTHROPOIETIN (Epo) may have effects on exercise capacity and physiological regulation beyond a simple increase in red cell mass and the associated improvement in oxygen transport (4). In the context of a larger study on this topic, Lundby and colleagues (11) also asked questions about the reliability of urine testing for recombinant human Epo (rHuEpo). They studied eight healthy male subjects...
متن کاملTesting for recombinant erythropoietin.
Erythropoietin (Epo) is a glycoprotein hormone that promotes the production of red blood cells. Recombinant human Epo (rhEpo) is illicitly used to improve performance in endurance sports. Doping in sports is discouraged by the screening of athletes for rhEpo. Both direct tests (indicating the presence of exogeneous Epo isoforms) and indirect tests (indicating hematological changes induced by ex...
متن کاملTesting for recombinant human erythropoietin in urine: problems associated with current anti-doping testing.
BACKGROUND the main action of recombinant human erythropoietin (rHuEpo) is to increase the oxygen carrying capacity of the blood. To prevent a possible misuse of rHuEpo, this is tested in urine samples collected from athletes by World Anti-Doping Agency (WADA)-accredited laboratories. Recently the test has met serious critiques, and the aims of the present study were to investigate the detectio...
متن کاملHyporesponsiveness to recombinant human erythropoietin.
The introduction of recombinant human erythropoietin (rh-Epo, epoetin) as a treatment for the anaemia of renal failure has transformed the management of this condition. Nevertheless, a significant number of patients fail to respond. There are many different possible causes of inadequate response to epoetin. Iron deficiency, whether absolute or functional, is considered to be the most important,...
متن کاملComments on Delanghe and Joyner’s Editorial “Testing for recombinant human erythropoietin”
TO THE EDITOR: In their recent editorial on the disappointing disagreement between two World Anti-Doping Agency (WADA)-accredited laboratories evaluating samples for detecting recombinant human erythropoietin (Epo) in urine, Delanghe and Joyner (4) concluded that blood-based indirect Epo tests offer an interesting alternative (2). This is ideally true, considering that the urine test is proven ...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2008
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.90746.2008